Quaternary derivatives of noroxymorphone which relieve intestinal immobility

US4176186A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Leon I. Goldberg · Potomac, US
• Herbert Merz · Ingelheim am Rhein, DE
• Klaus Stockhaus

Key dates

• Filing date: Jul 28, 1978
• Grant date: Nov 27, 1979
• Expiry date: Jul 28, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D489/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, and PA1 X is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion; the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.