Patent · US Expired

N-benzyl anthracyclines

US4177264A · kind A · utility

8Cited by

1References

15Claims

0Family size

Assignee

SRI International · US

Inventors

Helen Y. Wu · San Jose, US
Thomas H. Smith · East Palo Alto, US
David W. Henry · Chapel Hill, US

Key dates

Filing date	Oct 2, 1978
Grant date	Dec 4, 1979
Priority date	—
Expiry date	Oct 2, 1998

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H15/252
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and daunomycin, said derivatives having anticancer properties and being active against leukemia P-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibiting a loss of DNA-binding properties.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.