Disubstituted piperazines

US4177272A · kind A · utility

Assignee

• Science Union et Cie · FR

Inventors

• Gilbert Regnier · Le Plessis-Robinson, FR
• Roger Canevari · Élancourt, FR
• Michel Laubie · Vaucresson, FR
• Jean-Claude Poignant · Les Ulis, FR

Key dates

• Filing date: Dec 27, 1977
• Grant date: Dec 4, 1979
• Expiry date: Dec 27, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D285/135
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disubstituted piperazines of the formula: ##STR1## wherein: ##STR2## is naphthyl, benzo [b] furanyl, benzo [b] thienyl, benzodioxolyl, benzodioxanyl, benzodioxacycloheptanyl, coumaranyl, chromanyl, .DELTA..sup.3 -chromenyl, thiochromanyl or .DELTA..sup.3 -thiochromenyl, X is nitrogen and simultaneously Y is oxygen or sulfur, or X is sulfur, imino (NH) or methylimino (N CH.sub.3) and simultaneously Y is nitrogen, and R is hydrogen, lower alkyl, phenyl, halophenyl, lower-alkylphenyl or lower alkoxyphenyl. These compounds possess interesting pharmacological and therapeutic properties, and may be used as medicines, especially in the treatment of hypertension, peripheral vascular disorders and Parkinson's disease.