Pharmaceutical compositions of N.sub.1 -acyl-N.sub.2 -phenyldiaminopropanols and process for their preparation

US4177287A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Hans Liepmann · Hannover, DE
• Rolf Hueschens · Hannover, DE
• Wolfgang Milkowski
• Horst Zeugner
• Henning Heinemann · Hannover, DE
• Klaus-Ullrich Wolf · Burgdorf, DE
• Insa Hell · Hannover, DE
• Reinhard Hempel · Hannover, DE

Key dates

• Filing date: Apr 28, 1978
• Grant date: Dec 4, 1979
• Expiry date: Apr 28, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P1/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions are disclosed, which are effective in the treatment and prophylaxis of ulcers and which comprise as a pharmacologically active ulcus-inhibiting ingredient a compound selected from the group of N.sub.1 -acyl-N.sub.2 -(4-chlorophenyl)-1,3-diaminopropan-2-ols, having the formula I ##STR1## wherein R.sub.1 represents 3,4-dimethoxyphenyl, 2-fluorophenyl, 2-trifluoromethylphenyl, or furyl, and pharmaceutically acceptable acid addition salts thereof, and a pharmaceutically acceptable diluent. Further disclosed is a new process for the preparation of the compounds of formula I.