Tetrapeptide derivatives
US4178371A · kind A · utility
17Cited by
0References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 27, 1978 |
| Grant date | Dec 11, 1979 |
| Priority date | — |
| Expiry date | Nov 27, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1016
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tetrapeptide amides of the formula ##STR1## wherein R.sup.1, R.sup.8, R.sup.x, B and D represent certain specified substituent groups. The compounds exhibit pharmacological activity when tested in vitro in the transmurally stimulated guinea pig ileum preparation indicating their affinity for opiate receptor sites, and also in vivo tests, with intravenous administration, indicating their analgesic effects, and hence their utility as analgesic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.