New process for preparing pharmaceutical, cosmetic or diagnostic formulations
US4178695A · kind A · utility
Inventor
Key dates
| Filing date | Feb 6, 1978 |
| Grant date | Dec 18, 1979 |
| Priority date | — |
| Expiry date | Feb 6, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/84
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The process produces pharmaceutical, cosmetic or diagnostic formulations by the freeze drying of one or more substances in solution or in suspension in a solvent or a mixture of solvents. The solution or suspension is locally and progressively cooled in a controlled manner while agitating so as to produce microcrystals of solvent which are put in suspension in the remainder of the liquid until there is obtained a high-viscosity microcrystalline complex system comprising essentially isolated microcrystals of solvent in intimate mixture with interstitial liquid phases having a high concentration of the initially present substances. The microcrystalline complex system is hardened by cooling and lyophilized. This process permits the obtainment of lyophilized formulations having a higher dissolving or dispersing rate and lyophilized compositions of normally incompatible substances.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.