Microbiological degradation of sterol side chains to a 17-keto group

US4179336A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Alfred Weber · Wien, AT
• Mario Kennecke · Berlin, DE
• Helmut Dahl · Berlin, DE

Key dates

• Filing date: Jul 6, 1977
• Grant date: Dec 18, 1979
• Expiry date: Jul 6, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/863
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The side chains of sterols are degraded by fermentation with microorganisms capable of doing so in an improved manner by employing in such fermentations sterol derivatives of the formula ##STR1## wherein n is 1 or 2; R.sub.1 is H or lower alkyl, R.sub.2 is alkyl, whose chain optionally is interrupted by an oxygen atom, or when n is 2, also a hydrogen atom; and R.sub.3 is a sterol side chain.