Patent · US Expired

Preparation of N-(phosphonoacetyl)-L-aspartic acid

US4179464A · kind A · utility

3Cited by
2References
7Claims
0Family size

Inventors

Key dates

Filing dateAug 10, 1978
Grant dateDec 18, 1979
Priority date—
Expiry dateAug 10, 1998

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07F9/4006
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. Particular aspects of these methods include: (1) initial preparation of the PALA moiety as the dibenzyl ester; (2) the complete removal of impurities in the form of acetic acid and sodium acetate from disodium PALA by turbulent flow precipitation; and (3) preparation and purification of the cyclohexylammonium salt of dibenzyl PALA which ultimately results in a purer final product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.