2-Aryltropane compounds
US4179567A · kind A · utility
11Cited by
1References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 10, 1978 |
| Grant date | Dec 18, 1979 |
| Priority date | — |
| Expiry date | Apr 10, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the tropane (8-azabicyclo[3.2.1]octane) series having an aromatic substiutent in the 2-position and a carboalkoxy group in the 3-position are prepared by reacting a tropane-3-carboxylate having a double bond in the 2,3-position with an aryl Grignard reagent. Transformations of the substituent on nitrogen are subsequently effected. Compounds where the 3-carboalkoxy group is in the exo configuration possess hypoglycemic activity, and those where the 3-carboalkoxy group is in the endo configuration possess narcotic antagonist activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.