1-Piperazino-6-phenyl-4H-s-triazolo[3,4-c]thieno[2,3-e]1,4-diazepines

US4180573A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Karl-Heinz Weber · Gau-Algesheim, DE
• Adolf Langbein
• Claus Schneider · Ingelheim am Rhein, DE
• Erich Lehr · Waldalgesheim, DE
• Karin Boke · Ingelheim am Rhein, DE
• Franz J. Kuhn · Gau-Algesheim, DE

Key dates

• Filing date: Jul 13, 1978
• Grant date: Dec 25, 1979
• Expiry date: Jul 13, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, di(lower alkyl)amino-lower alkyl, phenyl, tolyl, methoxy-phenyl, nitro-phenyl, halo-phenyl, pyridyl, pyrimidinyl or --CO--R.sub.4, where R.sub.4 is hydrogen, alkyl or 1 to 17 carbon atoms, alkoxy of 1 to 2 carbon atoms, phenyl, tolyl, methoxy-phenyl, halo-phenyl, nitro-phenyl or pyridyl; PA1 R.sub.2 is hydrogen, fluorine, chlorine, or bromine; and PA1 R.sub.3 is chlorine, bromine or lower alkyl, and non-toxic, pharmacologically acceptable acid addition salts of certain of these compounds. The compounds as well as the salts are useful as anxiolytics, tranquilizers, sedatives or neuroleptics.