Certain nicotinamido-n-benzoic acid derivatives

US4181658A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Volker Hitzel · Hofheim, DE
• Rudi Weyer · Kelkheim, DE
• Karl Geisen · Frankfurt, DE
• Werner Pfaff · Hofheim, DE

Key dates

• Filing date: Feb 16, 1978
• Grant date: Jan 1, 1980
• Expiry date: Feb 16, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/82
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzoic acid derivatives of the formula ##STR1## wherein T is hydrogen or halogen, W is a carboxyl group, an ester or salt thereof; X is ##STR2## wherein R.sub.1 is alkyl having from 2 to 8 carbon atoms, aralkyl or phenyl, cycloalkyl, cycloalkylalkyl or alkylcycloalkyl; R.sub.2 is hydrogen or halogen, R.sub.3 is alkyl having from 5 to 8 carbon atoms, aralkyl or phenyl, or cycloalkyl having from 5 to 8 carbon atoms; R.sub.4 is hydrogen or alkyl; Y is a single chemical bond or a hydrocarbon chain having from 1 to 3 carbon atoms; and Z is hydrogen, halogen, alkyl, alkoxy, alkoxyalkoxy or alkenyloxy, have a blood sugar lowering effect and can be used for the treatment of Diabetes mellitus.