Quinoxalinone compounds useful for expanding the lumina or air passages in mammals

US4181724A · kind A · utility

Assignee

• The Upjohn Co. · US

Inventors

• Charles M. Hall · Kalamazoo, US
• Herbert G. Johnson · Kalamazoo, US

Key dates

• Filing date: Sep 11, 1978
• Grant date: Jan 1, 1980
• Expiry date: Sep 11, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/495
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula below are useful for expanding the lumina or air passages in a mammal in need of said treatment. The compounds are also useful for treating atopic eczema and urticaria. ##STR1## wherein X and Y are the same or different and are hydrogen, fluoro, chloro, bromo, nitro, trifluoromethyl, alkyl of one to four carbon atoms, inclusive, alkoxy of one to four carbon atoms, inclusive, and cyano; PA1 R.sub.1 is hydrogen, methyl or ethyl; PA1 R.sub.2 is hydrogen, alkyl of one to six carbon atoms, inclusive, phenyl, benzyl, PA1 CH.sub.2 Z wherein Z is fluoro, chloro, or bromo, PA1 CO.sub.2 M, CH.sub.2 CO.sub.2 M, CH.sub.2 CH.sub.2 CO.sub.2 M and CHR.sub.3 CO.sub.2 M wherein M is hydrogen, alkyl of one to four carbon atoms, inclusive, or a physiologically acceptable metal or amine cation and R.sub.3 is alkyl of one to three carbon atoms, inclusive, with the proviso that M is not hydrogen when R.sub.2 is CH.sub.2 CO.sub.2 M or a CHR.sub.3 CO.sub.2 M.