Process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes

US4182889A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Akiji Asai · Wennigsen (Deister), DE
• Ivan Ban · Hannover, DE
• Samuel David · Dorval, CA
• Peter W. Thies · Hannover, DE

Key dates

• Filing date: Aug 22, 1977
• Grant date: Jan 8, 1980
• Expiry date: Aug 22, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives is disclosed, wherein a 10-methylen-3-iodomethyl compound of the formula ##STR1## is hydrogenated to obtain a mixture of the corresponding epimeric 10.beta.- and 10.alpha.-methyl-3-iodomethyl compounds, the pure 10.alpha.- and 10.beta.-methyl epimers are separated and recovered from this mixture and are reacted with a secondary amine. Optionally, the substituent in the 4-position of the resulting 10.alpha.- or 10.beta.-methyl-3-aminomethyl compounds are further changed.