Phenylglycine-containing new peptides with gastrine effects and a process for the preparation thereof
US4183909A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1977 |
| Grant date | Jan 15, 1980 |
| Priority date | — |
| Expiry date | Dec 12, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel peptides of formula (I), EQU A-Try-B-Asp-Phg-NH.sub. 2 (I) wherein PA0 A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl or E-aminooxy-acyl, wherein E is benzoyl or straight-chained or branched C.sub.1-5 aliphatic acyl, and PA0 B represents methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, or acid addition salts or complexes thereof. The novel compounds according to the invention exert gastrin effects and can be applied to advantage in the diagnostics and therapy. The novel compounds of formula (I) are prepared according to the invention by reacting a tetrapeptideamide of formula (II), EQU H-Try-B-Asp-Phg-NH.sub. 2 (II) PA0 wherein B is as defined above, with an (aminooxy)-acyl containing compound of the general formula A.sub.1 -X, wherein PA1 A.sub.1 has the same meanings as A with the exception of the (aminooxy)-acyl, and PA1 X is hydroxy group, halogen, pivaloyloxy, a group of the formula R--O--CO.sub.2 -- (wherein R is lower alkyl, phenoxy which can have a nitro substituent or one or more halogen or N-succinimidoxy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.