Novel benzothienyl amino (propyl and butyl) ketones, a method of preparation thereof and their application to therapeutics
US4186136A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 31, 1976 |
| Grant date | Jan 29, 1980 |
| Priority date | — |
| Expiry date | Mar 31, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyl having one to 4 carbon atoms, allyl or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, RX is an inorganic acid, organic acid or an alkyl bromide or iodide, m is 3 or 4, and n is zero or one. The compounds are prepared by (1) reacting benzothienyl-lithium with ##STR3## followed by hydrolysis, or (2) when the substituent is located at the 2 position of the benzothienyl group, by reacting benzothiophene with ##STR4## followed by reaction with ##STR5## The compounds possess blood-plaque aggregation, spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vaso-dilatory properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.