Chenodeoxycholic acid recovery process
US4186143A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 9, 1978 |
| Grant date | Jan 29, 1980 |
| Priority date | — |
| Expiry date | Aug 9, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid. The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.