Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines
US4186199A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1978 |
| Grant date | Jan 29, 1980 |
| Priority date | — |
| Expiry date | Nov 2, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
What is disclosed are ##STR1## wherein X is hydrogen, halogen or trifluoromethyl; PA1 Y is hydrogen, halogen or trifluoromethyl; PA1 R is hydrogen, loweralkyl, cycloalkyl, phenyl, halophenyl, furyl, pyridinyl, 4-methylpiperazin-1-ylethyl or phenylloweralkyl; PA1 R.sup.1 is hydrogen; PA1 n and m are independently 0 or 1, but n is not 0 when m is 1, and the bonds between ring positions 1 and 2 and between positions 6 and 7 are respectively saturated when n and m are 1 and are unsaturated when n and m are 0; pharmaceutically acceptable acid addition salts thereof; methods of preparing said compounds; pharmaceutical compositions including said compounds; methods of treatment using the compounds; and intermediates therefor. These compounds are useful as analgesic and anti-inflammatory agents, as well as intermediates for the preparation of other pharmaceutically active compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.