Process for making 2-(4-isobutylphenyl)propionic acid and related compounds
US4186270A · kind A · utility
5Cited by
4References
11Claims
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Key dates
| Filing date | Dec 26, 1978 |
| Grant date | Jan 29, 1980 |
| Priority date | — |
| Expiry date | Dec 26, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Pure 2-(4-isobutylphenyl)propionic acid and related compounds are obtained in good yield by a multi-step process comprising chloromethylation of benzene or an alkylbenzene, conversion of the resulting benzyl chloride to the cyanide, alkylation of that product to the phenylpropionitrile or phenylbutyronitrile, reaction of unreacted benzyl cyanide with an aldehyde to inhibit its hydrolysis, and hydrolysis of the nitrile to the free acid. The products are antiinflammatory, antipyretic, and analgesic drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.