17 Beta-thiocarboxylic acid esters of 6 alpha, 6 beta-difluoro-3-oxoandrost-4-enes
US4187301A · kind A · utility
33Cited by
2References
21Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 5, 1978 |
| Grant date | Feb 5, 1980 |
| Priority date | — |
| Expiry date | Apr 5, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0031
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain 3-oxoandrost-4-ene and 3-oxoandrosta-1,4-diene 17 beta-thiocarboxylic acid esters substituted at the 6 alpha, 6 beta-positions with fluorine substituents are useful as anti-inflammatory steroids. These compounds are optionally substituted at the 9 alpha position with fluoro, chloro or bromo; substituted at the 11 with a keto-, a beta-hydroxy or a beta-chloro (the latter only when there is a 9 alpha-chloro); substituted at 16 alpha, 17 alpha-positions with isopropylidenedioxy; and substituted at 16 alpha (or 16 beta) with methyl or hydrogen when there is a 17 alpha-hydroxy (or an ester).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.