Benzodiazepine-diones, a process for their production and their use as medicaments

US4187306A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Karl Heinrich Mayer
• Helmut Heitzer · Leverkusen, DE
• Friedrich Hoffmeister
• Arend Heise · Wuppertal, DE
• Stanislav Kazda · Wuppertal, DE

Key dates

• Filing date: Jul 6, 1978
• Grant date: Feb 5, 1980
• Expiry date: Jul 6, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/91
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention covers compounds of the formula ##STR1## in which R.sup.1 and R.sup.5 each represents 0, 1, 2, 3 or 4 of the following substituents: alkyl, hydroxyl, acyloxy, alkoxy, nitro, amino, alkylamino, dialkylamino, acylamino, acylalkylamino, alkoxycarbonylamino, halogen, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulphonyl, alkylaminosulphonyl, dialkylaminoamino, R.sup.2 is hydrogen, optionally substituted alkyl, aralkyl or aryl or heterocyclo-alkyl, acyl or alkoxycarbonyl, and R.sup.3 and R.sup.4 are each hydrogen, or optionally substituted alkyl, aralkyl, aryl or hetero-aryl, are useful as medicaments which have an action on the central nervous system, in particular as, for example, tranquilizers and/or antiamnesics. Also included in the invention are methods for preparing said compounds, compositions containing them and methods for the use of said compounds and compositions.