1,2-Dihydro-2-oxoquinol-4-ylacetic acid derivatives and pharmaceutical compositions
US4187310A · kind A · utility
1Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1978 |
| Grant date | Feb 5, 1980 |
| Priority date | — |
| Expiry date | Sep 25, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.