1,4-Dihydropyridine derivatives substituted in the 2 position, and their use as medicaments

US4188395A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Friedrich Bossert
• Egbert Wehinger
• Horst Meyer
• Arend Heise · Wuppertal, DE
• Stanislav Kazda · Wuppertal, DE
• Kurt Stoepel · Wuppertal, DE
• Robertson Towart · Stoke Poges, GB
• Wulf Vater
• Klaus Schlossmann · Wuppertal, DE

Key dates

• Filing date: Dec 1, 1977
• Grant date: Feb 12, 1980
• Expiry date: Dec 1, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted, PA1 A represents a straight-chain or branched alkylene radical, PA1 R.sup.1 represents (a) an optionally substituted alkylthio group or (b) a group of the formula O--CO-alkyl, O--CO-aryl or O--CO-aralkyl, the alkyl and aryl groups being optionally substituted or (c) a phthalimido radical which is optionally substituted in the benzene ring, Y and Z are identical or different and each represents a group of the formula COOR.sup.2 or COR.sup.2, wherein PA1 R.sup.2 represents alkyl, alkenyl, alkinyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl or aralkyl, the alkyl and aryl radicals being optionally substituted, or PA1 Y and Z are identical or different and each represents a cyano radical or a radical of the formula S(O).sub.n --R.sup.3, wherein PA1 R.sup.3 represents alkyl, alkenyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, aryl or aralkyl, the alkyl and aryl radicals mentioned being optionally substituted, and n represents 0, 1 or 2, PA1 R.sup.4 represents …