1-[(10,11-Dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds
US4188485A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 16, 1978 |
| Grant date | Feb 12, 1980 |
| Priority date | — |
| Expiry date | Jun 16, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention encompasses 1-[10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methyl]-4-substituted piperidines and related compounds of the formula ##STR1## and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein R in each occurrence represents hydrogen, halogen, alkyl radical of 1 to 7 carbon atoms, or trifluoromethyl, alike or different; R.sup.1 is hydrogen or alkyl radical of 1 to 7 carbon atoms; Z is hydroxy or NR.sup.2 R.sup.3 group wherein R.sup.2 and R.sup.3 are each hydrogen or alkyl radical of 1 to 7 carbon atoms or R.sup.2 and R.sup.3 together with the N-atom represent an azamonocyclic ring which contains from 4 to 6 carbon atoms; X is ethylene, vinylene, oxy or thio; and m and n are each alike or different integer from 1 to 4 inclusive; and 1-(2,2-diarylethyl)-4-piperidinols of the formula ##STR2## and the non-toxic pharmaceutically acceptable acid addition salts thereof; wherein Ar is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms, alike or different; Ar.sup.1 is phenyl optionally substituted with one or more halogen or alkyl radical of 1 to 7 carbon atoms alike or different; and R.sup.4 is selecte…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.