Medicinal composition and its use as antidepressive agent

US4189478A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Karl-Heinz Schmitt · Benoni, ZA
• Irmgard Hoffmann · Bad Soden am Taunus, DE
• Werner Fulberth · Frankfurt am Main, DE
• Willi Stammberger · Hofheim, DE

Key dates

• Filing date: May 30, 1978
• Grant date: Feb 19, 1980
• Expiry date: May 30, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; ##STR1## in which R.sub.1, R.sub.3 and R.sub.4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R.sub.2 and R.sub.2 ', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R.sub.5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.