Method of preparing 4-methyl-5-hydroxymethyl-imidazole
US4189591A · kind A · utility
4Cited by
1References
4Claims
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Key dates
| Filing date | Jan 25, 1979 |
| Grant date | Feb 19, 1980 |
| Priority date | — |
| Expiry date | Jan 25, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/64
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The yield of 4-methyl-5-hydroxymethyl-imidazole from the known reaction between formaldehyde and 4-methyl-imidazole can be increased greatly if the reaction is performed in a concentrated aqueous medium at pH 11-13.5, preferably 12-13.5, at a temperature of 20.degree.-60.degree. C., preferably 30.degree.-40.degree. C., with an amount of formaldehyde not exceeding 1.5 mole per mole of 4-methyl-imidazole.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.