Synthesis of beta-lactams from azetidine carboxylic acid esters
US4190579A · kind A · utility
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7Claims
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Key dates
| Filing date | Dec 29, 1977 |
| Grant date | Feb 26, 1980 |
| Priority date | — |
| Expiry date | Dec 29, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D205/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.