Coriolin derivatives and process for producing the same

US4190589A · kind A · utility

Assignee

• NIPPON KAYAKU KABUSHIKI KAISHA · JP

Inventors

• Yuya Nakayama · Saitama, JP
• Mamoru Kunishima · Tokorozawa, JP
• Akira Matsuda · Sapporo, JP
• Tomio Takeuchi · Tokyo, JP
• Hamao Umezawa · Tokyo, JP

Key dates

• Filing date: May 4, 1978
• Grant date: Feb 26, 1980
• Expiry date: May 4, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Coriolin derivatives having antitumor activity and low toxicity represented by the following general formula: ##STR1## where R: --CO(CH.sub.2).sub.6 CH.sub.3 or --COCH(OH)(CH).sub.2).sub.5 CH.sub.3, PA1 X: .dbd.CH.sub.2 or --COOR', PA1 R': H or lower alkyl group. PA1 Y: OH or .dbd.O and PA1 Z: --OH or OCH.sub.3, as well as the process for producing the above derivatives are disclosed.