4,6-Di-O-(aminoglycosyl)-1,3-diaminocyclitols, process for their production and their use

US4190722A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eckart Voss · Cologne, DE
• Peter Stadler · Haan, DE
• Uwe Petersen · Leverkusen, DE
• Hans-Joachim Kabbe
• Karl G. Metzger · Wuppertal, DE

Key dates

• Filing date: Jun 6, 1978
• Grant date: Feb 26, 1980
• Expiry date: Jun 6, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention includes selectively acylated or sulphenylated 4,6-O-(aminoglycosyl)-1,3-diaminocyclitols (and methods for their preparation). Also included in the invention are 1-N-acylated-derivatives, such as 1-N-formyl-sisomicin, useful because of the anti-bacterial effects (and methods for their procurement). The invention includes, furthermore, methods for the procurement of said 1-N-acylated or sulphenylated derivatives, compositions containing them and methods for their use.