Instillation composition

US4191772A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Heinrich Woog · Hemsbach, DE
• Werner Rothe · Rellingen, DE
• Werner Gruber · Erkrath, DE

Key dates

• Filing date: Feb 24, 1978
• Grant date: Mar 4, 1980
• Expiry date: Feb 24, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/0043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An instillation composition, comprising an effective amount of at least one sparingly soluble active material suspended or partly dissolved in an aqueous emulsion containing a swelling agent. Advantageously the active substance is nitrofurantoin or a quinolone or pyridazine derivative, the active material has a particle size less than about 10 .mu.m and the swelling agent is a polysaccharide derivative present in about 0.3 to 3% by weight of the composition, the composition further containing at least one local anesthetic, antiphlogistic substance, emulsifier, buffer or stabilizer. With the invention, unit doses of only 50 ml. will contain sufficient active material.