Biphenyl derivatives

US4191776A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Josef Nickl
• Erich Muller · Zell am Harmersbach, DE
• Berthold Narr · Biberach, DE
• Walter Haarmann
• Wolfgang Schroter · Zell am Harmersbach, DE
• Rudolf Kadatz · Zell am Harmersbach, DE

Key dates

• Filing date: Nov 18, 1977
• Grant date: Mar 4, 1980
• Expiry date: Nov 18, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/185
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, methyl, methoxy, methylthio or cyano; PA1 R.sub.2 is hydrogen or fluorine; PA1 R.sub.3 is carboxyl, (alkoxy of 1 to 6 carbon atoms)-carbonyl, methoxy-(alkoxy of 1 to 6 carbon atoms)-carbonyl, (alkenyloxy of 2 to 6 carbon atoms)-carbonyl, (aralkoxy of 7 to 12 carbon atoms)-carbonyl, phenoxy-carbonyl or pyridyl-methoxy-carbonyl, PA1 A is (alkyl of 1 to 3 carbon atoms)-methylene, PA1 m is 1 or 2; and PA1 n is 0, 1, 2 or 3; and, when R.sub.3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base. The compounds as well as the salts are useful as antithrombotics, anticholesteremics and anticoagulants.