Maleic acid halfamides having blood pressure raising activity

US4191777A · kind A · utility

Assignee

• Deutsche Gold- und Silber-Scheideanstalt Vormals Roessler

Inventors

• Karl H. Kingler · Bad Tabarz, DE
• Klause Thiemer · Hanau, DE
• Fritz Stroman · Offenbach, DE

Key dates

• Filing date: Dec 13, 1978
• Grant date: Mar 4, 1980
• Expiry date: Dec 13, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are prepare half amides (semi-amides) of unsaturated aliphatic dicarboxylic acids of the formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, a hydroxy group, a methyl group or a methoxy group or two of these together are a methylenedioxy group, R.sub.4 is hydrogen or a methyl group, R.sub.5, R.sub.6 and R.sub.7 independently are hydrogen or C.sub.1 -C.sub.4 alkyl groups and n is 0 or 1 and their salts with the proviso that in the case of the free acids N[2-(3-hydroxyphenyl)-2-hydroxyethyl]-maleic acid monoamide is excluded. The compounds have blood pressure raising activity and also have antidepressive activity.