Rapid, large scale, automatable high pressure peptide synthesis
US4192798A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 20, 1978 |
| Grant date | Mar 11, 1980 |
| Priority date | — |
| Expiry date | Nov 20, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/29
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In the method for the synthesis of a polypeptide chain on an insoluble solid support wherein an amino acid is introduced into a reactor packed with an insoluble solid support containing substituent groups reactive with said amino acid, coupling said amino acid to said support by condensation reaction with said reactive substituent groups, introducing a second similar or dissimilar amino acid into said reactor and coupling said second amino acid to said first amino acid and repeating the process until the desired polypeptide is obtained, the improvement wherein a high pressure flow system is used and the reaction pressure in said reactor during said synthesis is at least 200 psi up to 10,000 psi or more, in order to obtain rapid reactions and quantitative yields of the desired products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.