Amides of pyrrolidinoethylamine which can be used in lung therapy
US4192883A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1978 |
| Grant date | Mar 11, 1980 |
| Priority date | — |
| Expiry date | Aug 7, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D311/84
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith. In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic,.alpha.-phenyl-.alpha.-ethylacetic, diphenylacetic, benzilic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 10-phenothiazinecarboxylic, benzoic, halobenzoic, 3-coumarincarboxylic, 9-xanthenecarboxylic, salicylic, cresotic, halocresotic, lower-alkoxybenzoic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, cinnamic, or 9-fluorene carboxylic acid, and wherein R'H represents an inorganic or organic acid, and wherein R may be, for example, a substituted aromatic ring of the formula: ##STR3## wherein R.sub.1 and R.sub.2 may independently be lower-alkyl, lower-alkoxy, hydrogen, lower-alkenyloxy, or lower-alkynyloxy, and X may be hydrogen or halogen. Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.