Patent · US Expired

Process for coupling biological substances by covalent bonds

US4193982A · kind A · utility

113Cited by

1References

13Claims

0Family size

Assignee

Etablissement Declare d'Utilite Publique Dit. Institut Pasteur · FR

Inventors

Stratis Avrameas · La Celle-Saint-Cloud, FR
Therese Ternynck · Paris, FR

Key dates

Filing date	Dec 1, 1976
Grant date	Mar 18, 1980
Priority date	—
Expiry date	Dec 1, 1996

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/866
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to couple antibodies to enzymes for determining or detecting said antibodies. The process can be used for the determination of antitetanic antibodies in human serum.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.