2-Alkylthio-, 2-alkylsulphinyl- and 2-alkylsulfonyl-6-phenylbenzimidazoles as anthelmintic agents

US4197307A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Jean J. Gallay · Luzern, CH
• Manfred Kuhne · Pfeffingen, CH
• Alfred Meyer · Basel, CH
• Oswald Rechsteiner · Binningen, CH
• Max Schellenbaum · Muttenz, CH

Key dates

• Filing date: Apr 10, 1978
• Grant date: Apr 8, 1980
• Expiry date: Apr 10, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Benzimidazole derivatives of the formula ##STR1## in which R is an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 3 to 5 carbon atoms, an alkynyl group having 3 to 5 carbon atoms or a benzyl group, which is unsubstituted or monosubstituted to disubstituted by a methyl group, halogen or a nitro group; PA0 R.sub.1 is hydrogen, an alkanoyl group having 1 to 4 carbon atoms, an alkoxycarbonyl group having 1 to 4 carbon atoms, a N,N-dialkylcarbamoyl group or N,N-dialkylthiocarbamoyl group, each having 1 to 4 carbon atoms in the alkyl groups, an alkylsulphonyl group having 1 to 4 carbon atoms, a benzoyl group, a phenylsulphonyl group, a 4-methylphenylsulphonyl group or the radical, ##STR2## in which Q is a carbonyl group, a thiocarbonyl group or an oxalyl group; PA1 R.sub.2 is hydrogen, halogen or a methyl group; PA1 R.sub.3 is hydrogen, halogen, a methyl group or an alkoxy group having 1 to 4 carbon atoms; PA1 R.sub.4 is hydrogen, halogen or a methyl group; X is oxygen or sulphur; PA1 Y is halogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a methylthio group, a methylsulphinyl group, a methylsulphonyl group, a trifluoromethyl …