Process for purifying thienamycin
US4198338A · kind A · utility
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2References
2Claims
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Assignee
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Key dates
| Filing date | Mar 13, 1978 |
| Grant date | Apr 15, 1980 |
| Priority date | — |
| Expiry date | Mar 13, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/803
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using a sequence of ion exchange resins, starting with an anion exchange resin of the polystyrene-trimethylammonium type in the HCO.sub.3 -cycle, and ending with absorption on and elution from a polymeric cross-linked polystyrene-type resin adsorbent. Variations in the intermediate steps, e.g. different resins and eluates are possible and are illustrated within.
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