Derivatives of 3-carboxyrifamycin S and SV and process for their preparation
US4200573A · kind A · utility
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18Claims
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Key dates
| Filing date | Dec 11, 1978 |
| Grant date | Apr 29, 1980 |
| Priority date | — |
| Expiry date | Dec 11, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New compounds being derivatives of 3-carboxyrifamycin S and SV are prepared by oxidation of cyanohydrin of 3-formylrifamycin S to 3-(cyanocarbonyl)rifamycin S, condensation with a compound of formula HR (an alcohol, an amine or an substituted hydrazine) and, optionally, reduction of the derivative of 3-carboxyrifamycin S so obtained to the corresponding SV form. Alternatively 3-(cyanocarbonyl)rifamycin S may be converted to the SV form before condensing with the compound HR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.