Therapeutic system for administering clonidine transdermally
US4201211A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jul 12, 1977 |
| Grant date | May 6, 1980 |
| Priority date | — |
| Expiry date | Jul 12, 1997 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB32B2556/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm.sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-clonidine reservoir lamina that is the source of the clonidine for the continuous constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-clonidine contact adhesive layer that is the source of the clonidine for the priming dose and the means by which the system is attached to the skin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.