Diamine-benzophenones and a process for the preparation thereof
US4201723A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1977 |
| Grant date | May 6, 1980 |
| Priority date | — |
| Expiry date | Jun 22, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 each is a saturated or unsaturated, straight-chained or branched alkyl group, an aralkyl group, a saturated or unsaturated cycloalkyl group or an aryl group, or PA1 R.sub.1 and R.sub.2 together with the adjacent nitrogen atom forms a substituted or unsubstituted heterocyclic group with or without a further oxygen or nitrogen heteroatom, and PA1 R.sub.3 is hydrogen or an acyl group derived from a C.sub.1-18 carboxylic acid. The compounds are prepared by reducing the corresponding nitro compounds of the formula (II) ##STR2## and optionally acylating the obtained product. The compounds of the formula (I) and their acid addition salts and quaternary ammonium salts are active primarily in the induction of liver microsomal enzymes, but they also possess valuable antipyretic activity and a yohimbine lethality increasing effect characteristic of antidepressants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.