Patent · US Expired

7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and processes for their preparation

US4201779A · kind A · utility

5Cited by

3References

5Claims

0Family size

Assignee

Hoechst GmbH · DE

Inventors

Dieter Bormann · Kelkheim, DE
Bernd Knabe
Elmar Schrinner · Wiesbaden, DE
Manfred Worm · Wiesbaden, DE

Key dates

Filing date	Mar 9, 1978
Grant date	May 6, 1980
Priority date	—
Expiry date	Mar 9, 1998

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D277/587
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Cephem derivatives of the formula ##STR1## in which R.sup.1 denotes hydrogen or low-molecular alkoxy, R.sup.2 denotes hydrogen, optionally substituted alkyl, phthalide or a cation, X denotes sulfur, oxygen or CH.sub.2 and A denotes hydrogen, alkoxy, halogen or a group --CH.sub.2 Y, in which Y represents hydrogen, acyloxy, alkoxy, optionally substituted carbamoyloxy or a group --SR.sup.3, in which R.sup.3 can represent acyl, alkyl or an optionally substituted 5-membered or 6-membered heterocyclic structure are disclosed as valuable antibiotics which are well suited for combating Gram-positive and in particular Gram-negative infections and also have an unexpectedly good action against penicillinase-forming staphylococci.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.