Drug activation by radiation
US4202323A · kind A · utility
18Cited by
1References
12Claims
0Family size
Inventors
Key dates
| Filing date | Apr 28, 1978 |
| Grant date | May 13, 1980 |
| Priority date | — |
| Expiry date | Apr 28, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K41/0042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of selectively causing drug activation within a living body which comprises administering to a living body a polyamino arylmethylnitrile capable of undergoing controlled cleavage to form a polyaminoaryl methyl ion and/or a free cyanide ion, the drug also being soluble in the body serum so that it is capable of passing via oral, intramuscular or intra-peritoneal administration into a body, and then subjecting a localized area of said body to radiation capable of causing cleavage of the cyanide ion from the drug precursor, the resulting ions acting to sensitize the localized area to radiation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.