Detection of hepatitis B surface antigen
US4202665A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 1978 |
| Grant date | May 13, 1980 |
| Priority date | — |
| Expiry date | Nov 6, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/82
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The reversed passive hemagglutination test (RPHA) for the detection of hepatitis B surface antigen (HB.sub.s Ag) is improved by the recognition that the speed of movement towards the periphery of a centrifugal field by immunologically aggregated solid phase support particles, increases proportionally with the amount of antigen present. It is further recognized that this dynamic study can be performed objectively and in an automated fashion by equipment such as the miniature centrifugal fast analyzer. The test performed in this manner and known as "reversed passive hemagglutination by minature centrifugal fast analysis" (RPHA/MCFA) is highly specific and eliminates the need for subsequent confirmational studies. Preliminary studies confirm a sensitivity comparable to other third generation tests.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.