N,N-pentamethylene derivatives of daunomycin and adriamycin

US4202967A · kind A · utility

Assignee

• SRI International · US

Inventors

• George L. Tong · Cupertino, US
• David W. Henry · Chapel Hill, US
• Helen Y. Wu · San Jose, US
• Thomas H. Smith · East Palo Alto, US

Key dates

• Filing date: Oct 2, 1978
• Grant date: May 13, 1980
• Expiry date: Oct 2, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/252
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described are N,N-pentamethylene derivatives of daunomycin and adriamycin having the formula: ##STR1## wherein R.sup.1 is --COCH.sub.3 or --CHOHCH.sub.3 in the case of daunomycin derivatives, or --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of adriamycin derivatives. The compounds have utility as antitumor agents.