Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4205060A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1978 |
| Grant date | May 27, 1980 |
| Priority date | — |
| Expiry date | Dec 20, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2989
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Microcapsules comprising a core containing a water-soluble salt of a medicament and a polymer, e.g., the salt of a medicament containing an amine-group and a carboxyl group containing polymer, and a sheath of a water-insoluble film forming polymer, e.g., ethyl cellulose, the method of their production and their administration are disclosed. The microcapsules can be formed by dispersing an aqueous solution of the medicament-polymer salt in a water-immiscible solvent solution of a water-insoluble film forming polymer, adding another water-immiscible solvent which is a non-solvent for the water-insoluble polymer, and collected the microcapsules. The microcapsules are administered orally to animals and exhibit substantially slower release rates and more uniform release rates in stomach acids than the corresponding unencapsulated salts or encapsulated non-polymeric salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.