Method for producing a biological reagent
US4206094A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1978 |
| Grant date | Jun 3, 1980 |
| Priority date | — |
| Expiry date | Sep 18, 1998 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00135
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polymeric functional microspheres containing metal or metal compounds are formed by addition polymerization of a covalently bondable olefinic monomer such as hydroxyethylmethacrylate in the presence of finely divided metal or metal oxide particles, such as iron, gold, platinum or magnetite, which are embedded in the resulting microspheres. The microspheres can be covalently bonded to chemotherapeutic agents, antibodies, or other proteins providing a means for labeling or separating labeled cells. Labeled cells or microspheres can be concentrated at a specific body location such as in the vicinity of a malignant tumor by applying a magnetic field to the location and then introducing the magnetically attractable microspheres or cells into the circulatory system of the subject. Labeled cells can be separated from a cell mixture by applying a predetermined magnetic field to a tube in which the mixture is flowing. After collection of the labeled cells, the magnetic field is discontinued and the labeled sub-cell population recovered.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.