Novel 17-substituted 11 .beta.-hydroxy steroids of the pregnane series, their manufacture, preparation and use

US4207316A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ernst Schottle · Berlin, DE
• Alfred Weber · Wien, AT
• Mario Kennecke · Berlin, DE
• Helmut Dahl · Berlin, DE
• Joachim-Friedrich Kapp · Berlin, DE
• Hans Wendt · Berlin, DE
• Klaus Annen · Berlin, DE
• Henry Laurent
• Rudolf Wiechert · Berlin, DE

Key dates

• Filing date: Jan 25, 1979
• Grant date: Jun 10, 1980
• Expiry date: Jan 25, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J71/0015
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Corticoids of the formula ##STR1## wherein represents a single bond or a double bond; PA1 X is hydrogen, fluorine, chlorine or methyl; PA1 Y is hydrogen and Z is hydrogen, fluorine or chlorine, or PA1 Y and Z together are a carbon-to-carbon bond; PA1 V is .beta.-hydroxymethylene, .beta.-chloromethylene or carbonyl; PA1 W is methylene, ethylidene or vinylidene; PA1 Q is oxygen or sulfur; PA1 R.sub.1 is alkyl of 1-8 carbon atoms, alkyl of 2-8 carbon atoms with an oxygen atom between two of the carbon atoms or benzyl, and R.sub.2 is hydrogen or alkyl of 1-4 carbon atoms, or PA1 R.sub.1 and R.sub.2 collectively are trimethylene or tetramethylene; and PA1 R.sub.3 is hydrogen, fluorine, chlorine, hydroxy, or hydroxy esterified by a C.sub.1-16 hydrocarbon carboxylic acid have valuable pharmacological properties, e.g., anti-inflammatory activity.