Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof
US4207319A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1978 |
| Grant date | Jun 10, 1980 |
| Priority date | — |
| Expiry date | Apr 14, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aromatic compounds having the following formula are disclosed: ##STR1## in which, A in the heterocyclic group is selected from the group of O and S; PA1 R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, are selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy; PA1 R.sub.5 is selected from the group consisting of hydrogen, lower alkyl and nitro; PA1 n is an integer from 1 to 3 and PA1 R.sub.6 and R.sub.7 together with the nitrogen atom to which they are attached form a 5- to 7-membered N-heterocyclic saturated group which optionally contain a second hetero atom, which may be O or N and pharmaceutically acceptable acid addition salts of the amino group thereof, said compound being in the form of the E isomer of the oximino group, the Z isomer or mixtures thereof. These novel compounds exhibit a coronary vasodilatory activity and may be used in the treatment of cardiopathies. A method of treating such disorders and a composition useful for treating same are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.