Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7
US4209616A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 16, 1978 |
| Grant date | Jun 24, 1980 |
| Priority date | — |
| Expiry date | Oct 16, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.