Vindesine synthesis
US4210584A · kind A · utility
1Cited by
1References
6Claims
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Assignee
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Key dates
| Filing date | Jan 15, 1979 |
| Grant date | Jul 1, 1980 |
| Priority date | — |
| Expiry date | Jan 15, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6561
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.