Reduction of indole compounds to indoline compounds
US4210590A · kind A · utility
3Cited by
5References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 6, 1978 |
| Grant date | Jul 1, 1980 |
| Priority date | — |
| Expiry date | Jan 6, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the corresponding indole compounds. A novel dioxyborane useful as a borane reagent is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.